Hull's new signing Aaron Mclean will be included in Nigel Pearson's squad for the first time after signing for an undisclosed seven-figure fee from Hull. Pearson will also be hoping goalkeeper Vito Mannone and defender Anthony Gerrard can shake off injury in time.
Mannone, on loan from Arsenal, was forced off late on in the 1-1 draw with Reading on Tuesday with a thigh injury while Gerrard, on loan from Cardiff, injured his Achilles during the warm-up and missed out.
Winger Richard Garcia has been ruled out for four weeks as he must have surgery on his injured knee. The Australia international also misses out for his country in this month's Asian Cup.
Midfielder Jimmy Bullard, working his way back from knee ligament damage, is hoping to play a bigger role after stepping off the substitutes' bench in the last two matches.
Chris Kirkland and Curtis Davies are major doubts for Leicester ahead of the game.
Goalkeeper Kirkland aggravated a long-standing back injury against Millwall on Tuesday while defender Davies is still struggling with the knee injury that forced him to miss the 2-0 defeat at The Den.
Kirkland's stop-start loan spell is due to finish after the game at the KC Stadium and the Barwell-born stopper has already returned to Wigan for treatment.
Chris Weale replaced Kirkland at half-time against Millwall and he is poised to come back into the team.
Miguel Vitor has missed the last two matches with a groin strain and the defender remains a doubt.
The Foxes have won just one of their last five games, losing three of them.