Swansea manager Brendan Rodgers is again likely to rotate his line-up as he looks to complete a league double over his former employers.
Rodgers made six changes for Tuesday's 1-0 triumph over Barnsley from the side smashed 4-0 at QPR on Boxing Day.
The former Royals boss, who triumphed 1-0 at the Madejski Stadium in October, insisted the switches were not as a result of the heavy Loftus Road defeat but part of a pre-arranged plan to utilise his squad over the hectic festive period.
The likes of Garry Monk, Joe Allen and Scott Sinclair were all dropped to the bench against the Tykes and are likely to be restored this weekend.
Striker Jermaine Easter was one of those who came in to make what was his first start for City and he will be hoping to retain his place having grabbed the only goal to see off Mark Robins' side.
One player who will definitely be missing at the Liberty Stadium is left-back Alan Tate who has seen the appeal against his Boxing Day dismissal at QPR turned down, meaning Neil Taylor is likely to step in.
Reading, meanwhile, could hand a start to Simon Church.
Church came off the bench to fire in a late equaliser at Hull on Tuesday and is hoping to dislodge fellow strikers Shane Long or Noel Hunt in Brian McDermott's line-up.
Club captain Ivar Ingimarsson (hamstring) completed 90 minutes for the reserves earlier this month and the defender could be involved for the first time this season.
His Icelandic compatriot Brynjar Gunnarsson (knee) is also back in training but the defensive midfielder is not expected to start.
McDermott has no other injury problems as he looks to build on an eight-match unbeaten streak.
Rodgers lasted just 23 games in charge of the Royals before he was sacked last December.