Edin Dzeko may have to be content with a place on the bench as City look to secure top spot for 24 hours.
The £27million Bosnian has not played a competitive game since scoring a last-minute equaliser for Wolfsburg against Hoffenheim prior to the German winter break and Roberto Mancini is cautious about pitching him straight in against Mick McCarthy's men.
Mario Balotelli (knee) and Micah Richards (back) have been ruled out but David Silva is expected to be available after missing two games with a knee injury.
Wolves have a trio of players - including skipper Karl Henry - back available at Eastlands.
Manager Mick McCarthy confirmed midfielder Henry (knee) and defenders Jody Craddock (hip) and Steve Mouyokolo (back) will all travel to Eastlands after recovering from injury.
Henry could replace hamstring victim Dave Edwards who was on target in Wolves 2-1 home win over City earlier this season.
Full-back George Elokobi will start a three-game ban for his red card in the FA Cup tie at Doncaster last weekend and he is likely to be replaced by Stephen Ward.
Manchester City (from): Hart, Given, Zabaleta, Boateng, K Toure, Kompany, Boyata, Kolarov, Lescott, Wright-Phillips, Johnson, De Jong, Vieira, Milner, Y Toure, Silva, Barry, Tevez, Dzeko, Adebayor, Jo.
Wolves (from): Hennessey, Hahnemann, Zubar, Stearman, Berra, Ward, Hunt, Foley, Milijas, Jarvis, Fletcher, Doyle, Jones, Henry, Craddock, Winnall, Doherty, Mujangi Bia, Mouyokolo, Ebanks-Landell, Rooney.