West Ham forward Victor Obinna is suspended after being sent off against Birmingham in the Carling Cup in midweek.
Lars Jacobsen returns after a lengthy lay-off and Danny Gabbidon is available after missing the cup tie.
Carlton Cole is also fully fit and could start against Arsenal after scoring as a substitute against Birmingham.
Arsenal will be without goalkeeper Lukasz Fabianski (shoulder), where Wojciech Szczesny will again deputise.
Centre-back Sebastien Squillaci (hamstring) is also out and right-back Bacary Sagna serves the last of his three-match ban.
Denilson has recovered from a thigh problem, while both Robin van Persie and Samir Nasri return to the squad having been rested for the midweek Carling Cup defeat at Ipswich.
Midfielder Abou Diaby (calf), goalkeeper Manuel Almunia (ankle), Abou Diaby (calf) and centre-back Thomas Vermaelen (Achilles) remain out.
West Ham (from): Green, Faubert, Jacobsen, Bridge, Tomkins, Reid, Gabbidon, McCarthy, Upson, Spector, Sears, Hines, Noble, Kovac, Parker, Piquionne, Cole, Boffin, Boa Morte, Nouble, Spence.
Arsenal (from): Szczesny, Eboue, Djourou, Koscielny, Gibbs, Song, Fabregas, Nasri, Wilshere, van Persie, Chamakh, Shea, Arshavin, Walcott, Ramsey, Bendtner, Miquel, Clichy, Rosicky.