Wigan have Charles N'Zogbia back after the winger completed a three-match suspension.
Goalkeeper Chris Kirkland missed last weekend's FA Cup third-round victory at Hull following the bang to the head he suffered in the previous game against Bolton and will have his condition assessed.
Mauro Boselli will not feature as he has been nursing a hamstring problem and is set to join another club on loan for the rest of the season.
Tom Cleverley's hamstring injury continues to keep him sidelined, while Latics boss Roberto Martinez hopes James McCarthy, Franco Di Santo (both ankle) and Victor Moses (shoulder) will be close to full fitness again by the end of the month.
Steve Sidwell could make his Fulham debut as Moussa Dembele and Andy Johnson return from injury.
New signing Sidwell is lacking match practice following last week's move from Aston Villa but the midfielder is in contention for the trip to the DW Stadium.
Dembele (ankle) could finally make his comeback, while Johnson is fit following a minor hamstring tear, but Bobby Zamora (leg), Philippe Senderos (Achilles) and Matthew Briggs (calf) are still out and Mark Schwarzer is on Asian Cup duty with Australia.
Wigan (from): Al Habsi, Pollitt, G Caldwell, Gohouri, Stam, Figueroa, Alacaraz, Watson, Diame, McArthur, Thomas, N'Zogbia, McManaman, Rodallega, Lopez, Gomez, S Caldwell, Robinson, Boyce, De Ridder, Golobart, Mustoe, Kirkland.
Fulham (from): Stockdale, Pantsil, Hangeland, Hughes, Baird, Davies, Riise, Murphy, Sidwell, Etuhu, Duff, Dempsey, E Johnson, Kamara, Gera, Dembele, Etheridge, Salcido, Greening, A Johnson, Halliche.