Inigo Calderon returns to the Brighton squad for the visit of Peterborough.
The Spaniard has completed a three-match ban for his red card against Charlton and should slot straight back in at right-back in place of 37-year-old assistant manager Mauricio Tarrico.
Goalkeeper Casper Ankergren, defender Gordon Greer and midfielder Gary Dicker were rested for the FA Cup win over Portsmouth on Saturday and should return.
Boss Gus Poyet started with three strikers against Pompey so one of Ashley Barnes, Glenn Murray and Chris Wood could drop to the bench.
Full-back Jim McNulty is out for the season after suffering an ankle injury while on loan at Scunthorpe, and midfielder Alan Navarro continues his rehabilitation from a cruciate knee ligament injury.
Peterborough manager Darren Ferguson will be without Gabriel Zakuani as he begins his second stint in charge of Posh.
The DR Congo international dislocated his shoulder in the midweek defeat of Brentford and could be out for as long as two months.
That should see Kelvin Langmead return to the starting line-up as Ferguson looks for a winning start back at the helm.
Loan signings Kieran Agard and Jonathan Obika will both be on the bench after Obika came on to score the winner in midweek while Joe Lewis will start in goal.
The England Under-21 international has handed in a transfer request at London Road after setting his sights on a move to the top flight but the club are yet to receive a suitable offer so he will play on.
Midfielder Charlie Lee - a staple of the side in Ferguson's first spell - is battling an ankle injury but could return while Lee Frecklington is now fit after an ankle injury.