Sheffield Wednesday's recent signings Michael Morrison and Reda Johnson are expected to make their home debuts against Charlton.
The 22-year-old defenders, both signed on a permanent basis for undisclosed fees from Leicester and Plymouth respectively last week, went straight into the starting line-up at Bristol City on Saturday.
The Owls are still without defenders Jon Otsemobor (calf) and Lewis Buxton (hamstring), so Morrison is likely to start again at right-back.
Midfielder Giles Coke has returned to full training following his recent knee operation, but will not be in contention this weekend, so James O'Connor could partner Tommy Miller again in central midfield. Darren Potter is also in contention.
The Owls, 3-0 winners in their FA Cup clash at Bristol City, have lost their last two league matches.
Nathan Eccleston will go straight into Charlton's squad.
The 20-year-old Liverpool striker has joined on loan until the end of the season and is set to make his debut as the managerless Addicks chase their first league win since November.
Ipswich loanee Lee Martin returns after he was ineligible to play in the FA Cup defeat at Tottenham last Sunday, but fellow forward Paul Benson is in the middle of a three-match ban.
Two more strikers, Akpo Sodje (shoulder) and Joe Anyinsah (groin), came through unscathed against Spurs after their recent spells on the sidelines and will be available again.
Full-backs Chris Solly (ankle) and Kelly Youga (knee) remain long-term absentees.