Injury-hit Newcastle will be without a host of first-team regulars after more bad news for manager Alan Pardew this week.
Alan Smith could miss the rest of the season with the ankle injury he sustained in the 1-1 draw at Sunderland last weekend while leading scorer Andy Carroll is recovering slower than expected from his thigh strain.
Dan Gosling made his return from a serious knee injury last weekend but is now out again after the joint swelled up, and he joins Steven Taylor (hamstring), Sol Campbell (leg), Hatem Ben Arfa (double leg fracture) and Ryan Taylor (ankle ligaments) on the sidelines.
Captain Kevin Nolan has a throat infection but will start while midfielder Cheik Tiote serves the second instalment of a three-match ban following his sending-off in the FA Cup defeat by Stevenage. Wayne Routledge is also unlikely to be involved after Newcastle accepted a bid from QPR to take him on loan.
Steven Pienaar is available to make his Tottenham debut.
Benoit Assou-Ekotto and Wilson Palacios are doubtful after they both picked up minor knee injuries in training this week and Ledley King continues to be sidelined by a groin problem.
Long-term absentees Jonathan Woodgate (groin), Jamie O'Hara (back) and Tom Huddlestone (ankle) are also unavailable.
Newcastle (from): Harper, Krul, Simpson, Perch, Ferguson, Enrique, Coloccini, Williamson, Barton, Nolan, Gutierrez, Guthrie, Vuckic, Donaldson, Ameobi, Lovenkrands, Best, Ranger.
Spurs (from): Gomes, Pletikosa, Cudicini, Hutton, Corluka, Dawson, Kaboul, Gallas, Bassong, Assou-Ekotto, Sandro, Palacios, Jenas, Bale, Lennon, Modric, Dos Santos, Van der Vaart, Crouch, Pavlyuchenko, Keane, Defoe, Pienaar.