Portsmouth's already threadbare squad will be weakened further by the absence of skipper Aaron Mokoena.
The South African defender starts a two-game ban after collecting his 10th yellow card of the season at Nottingham Forest last weekend.
Pompey are still without striker Dave Kitson, who is halfway through a three-match ban, but versatile defender Greg Halford is back from suspension.
Forward John Utaka suffered a hamstring injury at Forest and is a doubt but winger Nadir Ciftci, who missed out with an ankle problem, has trained this week and should feature.
Defender Ricardo Rocha has been on the bench recently despite hamstring trouble and could be called upon to start.
Danny Webber (cruciate) is still out and Richard Hughes and Michael Brown cannot play due to contract issues.
Leeds defender Andy O'Brien will miss the game.
The former Bolton centre-half will not face one of his former clubs after picking up a hamstring strain in the midweek FA Cup defeat to Arsenal.
Neill Collins or Leigh Bromby are likely to come into the starting line-up.
Striker Luciano Becchio missed out against the Gunners and is also rated as a doubt by manager Simon Grayson, though his chances of playing seem brighter due to having been rested in midweek with a niggling back problem.
Striker Mike Grella is poised to join Motherwell on loan until the end of the season while left-back George McCartney is available again after he was not allowed to play in the Cup tie.