Managerless Wednesday's latest signing Isaiah Osbourne is expected to feature at some stage in the home clash with the Dons.
Assistant manager Rob Kelly and coach Billy Barr will take charge following the sacking of Alan Irvine this week.
Osbourne was signed on loan from Aston Villa until the end of the season last weekend, but was not included in the squad for the midweek defeat at Peterborough.
Midfielder Darren Potter will sit out a one-game ban following his dismissal on Tuesday night, but Kelly and Barr have no other new injury or suspension problems.
Strikers Clinton Morrison and Paul Heffernan are pushing for recalls after new signing Gary Madine started alongside Neil Mellor against Peterborough.
Midfielders Tommy Miller (hamstring) and Liam Palmer (ankle) plus defenders Lewis Buxton (hamstring) and Jon Otsemobor (calf) are still sidelined.
The Dons will be without defender Sean O'Hanlon for the trip north to take on Wednesday.
The centre-half scored after just 45 seconds in the win at Bristol Rovers on Wednesday but was later sent off for two bookable offences and will serve a one-match ban at Hillsborough.
Gary MacKenzie is likely to return to the starting line-up in his place.
On-loan Fulham youngster Keanu Marsh-Brown made his professional debut in midweek and should again be on the bench while fellow January signings David Amoo and Rowan Vine will also be in the squad.
Striker Sam Baldock is still out with his hamstring injury and on-loan QPR striker Angelo Balanta will be out of action until March with an ankle problem.
Defender Jude Stirling was on the bench in midweek for the first time all season after finally recovering from a long-term hernia problem. Didi Hamann - who has not played since October as he focussed on coaching - has left to join Leicester.