Paul Rachubka looks set for a lengthy spell on the sidelines after damaging his knee yesterday in a suspected recurrence of the injury that kept him out for the first half of the season.
Fellow stopper Matt Gilks, who has not played since November due to a knee problem of his own, is still several weeks away from a return to action so Richard Kingson is in line to start against Villa, while Holloway hopes to be granted permission by the Premier League to sign another goalkeeper.
Stephen Crainey (ankle) is still out while January arrivals Sergei Kornilenko and Salaheddine Sbai are not yet ready to make their debuts.
Aston Villa striker Gabriel Agbonlahor is available.
Agbonlahor withdrew from the England squad for the midweek friendly in Denmark for "family reasons" but should feature in club action this weekend. On-loan midfielder Michael Bradley is in contention to make his debut after a full week's training.
Fellow midfielder Jean Makoun has overcome the calf strain which led to him being withdrawn from Cameroon's squad to face Macedonia on Wednesday but left-back Nathan Baker is still suspended after his sending-off against Blackburn in the FA Cup.
Blackpool (from): Kingson, Southern, Eardley, Cathcart, Evatt, Adam, Phillips, Vaughan, Varney, Taylor-Fletcher, Campbell, Sylvestre, Grandin, Euell, Beattie, Reid, Puncheon, Ormerod, Edwards, Baptiste, Harewood, Carney.
Villa (from): Friedel, Marshall, Walker, Collins, Dunne, Cuellar, Clark, Albrighton, Bannan, Petrov, Bradley, Makoun, Reo-Coker, Downing, Young, Agbonlahor, Delfouneso, Bent, Heskey.