Adam Lallana is in line to return to the Southampton squad for the visit of Carlisle.
The midfielder has been missing for a month with a knee injury but is back in full training and should be involved.
Veteran striker David Connolly is also fit after a hernia operation and could be on the bench, but midfielder Morgan Schneiderlin is still missing with the calf injury which kept him out of last week's 4-4 draw at Peterborough.
Captain Dean Hammond returned from a spell out with a calf problem against Posh and came through unscathed so he will partner Richard Chaplow in the centre of midfield again.
Winger Lee Holmes is a long-term absentee and will not play again this season after an ankle operation.
Carlisle's latest signing Gary Borrowdale is expected to make his first league appearance for the Cumbrians at Southampton.
QPR defender Borrowdale made his debut in the midweek Johnstone's Paint Trophy defeat at Huddersfield after arriving for an initial month-long loan spell.
Cumbrians manager Greg Abbott has no new injury or suspension problems, but could still be without skipper Paul Thirlwell (calf) and on-loan defenders Joe Dudgeon (knee) and Liam Cooper (hand), who all missed Tuesday night's Northern Area final clash, which saw Abbott's side hold on for a 4-3 aggregate win.
Striker Rory Loy, a recent permanent signing from Rangers, was included in the midweek starting line-up and is poised to make his first league start as Carlisle bid to halt a run of three straight defeats.