Reading will hand a late fitness test to goalkeeper Adam Federici.
The Australian was forced off with six minutes remaining of the 1-1 draw with Watford on Saturday and faces a check on his knee injury.
If he is ruled out, England Under-21 international Alex McCarthy - who played almost all of last season on loan at Yeovil - will make his first league start for the club.
Striker Mathieu Manset is a doubt with the calf injury which kept him out at the weekend while defender Alex Pearce is unlikely to return from his thigh problem.
Midfielder Jem Karacan remains out as he completes a three-match ban as Brian McDermott's side look for a first win in seven games.
Hameur Bouazza is pushing to make his full Millwall debut when they travel to the Royals.
The former Watford and Fulham winger, who had a knee injury when he signed for the Lions at the end of January, came on as a substitute against Middlesbrough on Saturday and marked his first appearance with a goal in the 3-2 defeat.
Millwall's recent injury crisis has eased with defenders Tony Craig (back) and Darren Ward (ankle) back on the bench at the weekend.
Midfielder Tamika Mkandawire is close to returning from a muscle strain and striker Josh McQuoid is due back in training this week after ankle trouble.
Defender Jens Berthel Askou did not make the squad on Saturday and his loan from Norwich has now expired.