Emmerson Boyce is Wigan's only major injury concern ahead of the game.
The defender is yet again troubled by the hamstring injury which has dogged his season and will be assessed before the game.
Callum McManaman is also a slight doubt after suffering a nasty cut in last week's FA Cup fourth round loss to Bolton.
Goalkeeper Ali Al Habsi should return after being ineligible to face his parent club while new signing Conor Sammon is also back in contention.
Michael Owen returns to the United squad for the game.
It was feared Owen's season was in jeopardy when he suffered a groin injury in training last week but happily, the former England star has recovered and could feature at the DW Stadium.
Ryan Giggs is also in contention but Rio Ferdinand (calf), Jonny Evans and Antonio Valencia (both ankle), Park Ji-sung (hamstring) and Anderson (knee) remain sidelined.
Wigan (from): Al Habsi, G Caldwell, Stam, Lopez, S Caldwell, Diame, Gomez, McCarthy, Thomas, McArthur, Di Santo, McManaman, Moses, Redmond, Mustoe, Golobart, Watson, Sammon, Alcaraz, Boyce, Cleverley, Gohouri, Pollitt, Kirkland.
Man United (from): Van der Sar, Kuszczak, Lindegaard, Vidic, O'Shea, Brown, Rafael, Fabio, Evra, Smalling, Scholes, Gibson, Nani, Carrick, Fletcher, Bebe, Obertan, Giggs, Tunnicliffe, Rooney, Owen, Berbatov, Hernandez, King.