Wolves striker Kevin Doyle has been declared fit for the game.
The Republic of Ireland international suffered a painful blow to the hips during the 1-1 derby draw with West Brom but has now resumed training and will lead the attack against the Tangerines.
Midfielder Stephen Hunt is still sidelined with a calf injury but Wolves boss Mick McCarthy has no fresh injury worries for what he has described as a "must-win" game.
Blackpool captain Charlie Adam starts a two-match suspension after picking up his 10th yellow card of the season in the 3-1 win over Tottenham on Tuesday.
In the meantime, the Scotland midfielder is seeing a specialist about a problem which is believed to be abdominal.
Striker Luke Varney should be involved again having been rested for the Spurs game, but Elliot Grandin and Gary Taylor-Fletcher (both hamstring) remain sidelined.
Stephen Crainey has returned to training following his ankle injury, although it is too soon for a first-team return.
Wolves (from): Hennessey, Zubar, Stearman, Berra, Elokobi, Foley, Henry, Milijas, Jarvis, O'Hara, Doyle, Hahnemann, Craddock, Ebanks-Blake, Fletcher, Ward, Jones, Hammill, Edwards.
Blackpool (from): Kingson, Southern, Eardley, Cathcart, Evatt, Phillips, Vaughan, Varney, Campbell, Sylvestre, Beattie, Reid, Puncheon, Ormerod, Baptiste, Harewood, Carney, Halstead, Kornilenko.