Hibernian will be without Ian Murray, Steven Thicot and Michael Hart for the game, while Danny Galbraith is a major doubt.
Captain Murray is set to serve the second of a two-match ban, Thicot (hip/thigh) and Hart (knee) are injured and Galbraith (ankle) is unlikely to be fit.
Graham Stack is set to continue in goal, with midfielder Kevin McBride available again following a ban.
David Proctor will miss out for Inverness after suffering a recurrence of a hamstring problem.
But Caley Thistle manager Terry Butcher is optimistic that Jonny Hayes will recover from a foot knock and Grant Munro returns from suspension.
Nick Ross, Gavin Morrison and Kenny Gillet are back in training following injury but might not make the Easter Road clash, while Dani Sanchez (hand) remains out.
Hibernian (from): Stack, Smith, Dickoh, Towell, Hanlon, Booth, Wotherspoon, Nish, Riordan, Rankin, Stevenson, Duffy, Galbraith, Trakys, Thornhill, Brown, Miller, Scott, Palsson, Sodje.
Inverness (from): Esson, Innes, Duff, Doran, Odhiambo, Foran, Rooney, Munro, Duncan, Tuffey, Sutherland, Hogg, MacDonald, Hayes, Ross, Cox, Tokely, Gillet.