Kolo Toure will be the notable absentee for City as he begins an indefinite suspension pending a full inquiry into his failed drugs test. Under Football Association rules the Ivorian will not be considered until the case is resolved.
Vincent Kompany is expected to return in central defence following a hip problem, while Nigel de Jong may be fit to claim a place on the bench after a six-game absence with an ankle injury.
Wigan's only absentee is likely to be Emmerson Boyce.
Boyce has been plagued by hamstring trouble this season and could also miss the next game against Birmingham in a fortnight's time.
On-loan midfielder Tom Cleverley is back in contention after being ineligible to face parent club Manchester United last weekend and January signing Connor Sammon could make his debut for the relegation-threatened Latics.
Manchester City (from): Hart, Taylor, Richards, Kompany, Lescott, Boateng, Boyata, Kolarov, Zabaleta, Wright-Phillips, Barry, De Jong, Vieira, Y Toure, Milner, M Johnson, Silva, Dzeko, Tevez, Balotelli, Jo.
Wigan (from): Al Habsi, G Caldwell, Gohouri, Figueroa, Alcaraz, Watson, N'Zogbia, Diame, Moses, McCarthy, Rodallega, Stam, Lopez, Thomas, Gomez, McArthur, McManaman, Cleverley, S Caldwell, Sammon, Di Santo, Pollitt, Kirkland.