Preston boss Phil Brown will assess the fitness of several players.
Goalkeeper Andy Lonergan and defender Craig Morgan missed Saturday's 1-1 draw at Norwich with a gastric-flu bug.
Striker Nathan Ellington turned his ankle during the warm-up and his place in the starting line-up went to Paul Hayes.
Midfielder Barry Nicholson picked up a calf injury in the first half at Carrow Road and defender Leon Cort sustained a hamstring strain.
David Gray left the pitch on a stretcher with a shin injury in the closing stages and Sean St Ledger and Billy Jones also picked up knocks.
Brown will check on all of his walking wounded as he seeks to record his first win since his appointment in January.
Leeds' latest loan signing Barry Bannan will go straight into the squad for the clash.
The 21-year-old Scotland international, who will stay at Elland Road until the end of the season, is expected to feature at some stage.
Manager Simon Grayson, who has no new injury or suspension worries, has the option of recalling skipper Richard Naylor to his starting line-up.
Central defender Naylor, who made his first appearance since mid-October when stepping off the substitutes' bench against Doncaster on Saturday, had knee surgery in November.
Grayson has plenty of options in defence, with Alex Bruce hoping for a recall after making way for Leigh Bromby on Saturday, and also in attack.
Billy Paynter, Ross McCormack, Davide Somma and Sanchez Watt all started on the bench at the weekend and are hoping to play their part in Leeds' promotion push.