Oldham boss Paul Dickov could be boosted by the return of skipper Reuben Hazell.
The defender has missed the last two matches due to a back injury but has returned to light training and may come into contention to face the Owls.
Midfielder Dean Furman was set to return after a two-match ban but his hopes may have been dashed after he was struck down by illness.
Furman will be assessed by medical staff before a decision is made on his availability as the Latics bid to bounce back from Saturday's 3-0 defeat at Bournemouth.
Dickov's men now lie nine points adrift of the top six but the former Manchester City striker said: "I believe we're still very much in the mix for a place in the play-offs."
Sheffield Wednesday manager Gary Megson is expected to choose from an unchanged squad.
Megson has no new injury or suspension problems, but could make changes following Saturday's home defeat to Plymouth.
Winger Jermaine Johnson returned to the squad on Saturday following a month-long lay-off due to illness and appeared as a half-time substitute against Plymouth.
The Jamaica international had hospital tests after complaining of dizziness at the end of the home draw with MK Dons in early February, but has since been given the all-clear and returned to full training last week.
Midfielder Giles Coke stepped off the bench to score a fine goal for the Owls against Plymouth and could force his way back into Megson's starting line-up following his recent three-game ban.
The Owls, who have won only one of their last seven games under Megson, are only five points clear of the relegation zone.