Brighton boss Gus Poyet could have defender Marcos Painter available when his side go in search of their fourth successive league win.
The Seagulls left-back had to be stretchered off in the 80th minute of Tuesday night's 1-0 win at Brentford after suffering a nasty kick to the head, but is expected to recover in time to retain his place in the starting line-up.
Fellow defender Adam El-Abd is pushing for a recall on his return from a two-match ban, and will fight it out with Tommy Elphick for the right to partner Gordon Greer at the centre of Albion's defence.
Defender Jim McNulty (ankle) and midfielder Jamie Smith (foot) both remain sidelined as they continue their recovery from long-term injuries.
Tranmere manager Les Parry is set to the wield the axe when his side make the trip.
Rovers were beaten 1-0 at home by relegation rivals Bristol Rovers on Tuesday night and Parry spared only Andy Robinson and John Welsh from criticism.
His attempts to bring in a new midfielder on loan failed but Parry will still ring the changes for the daunting clash with Gus Poyet's table-toppers.
However, he will first assess the fitness of defenders Ian Goodison and Mark McChrystal, who are struggling with knee and rib injuries respectively.
Teenage prospect Dale Jennings has been sidelined with a groin injury for the past month and Parry is wary of rushing him back into action too soon.
Marlon Broomes, Alan Mahon and Ryan Fraughan remain long-term absentees, but Rovers have extended the loan of teenage winger Lateef Elford-Alliyu from West Brom until early April.