Jonny Evans and Park Ji-sung are set to return for United.
United are still beset by injuries though, with skipper Nemanja Vidic remaining on the sidelines with a calf problem where he is joined by Rio Ferdinand, Darren Fletcher, John O'Shea and Rafael amongst others.
Red Devils boss Sir Alex Ferguson will not be there either as he starts a five-match touchline ban after accepting his punishment by the Football Association on Thursday.
Bolton have on-loan striker Daniel Sturridge available again.
Sturridge, who has scored four goals in five games for Wanderers since joining from Chelsea in January, was ineligible for last weekend's FA Cup quarter-final victory at Birmingham and is expected to return to the side despite picking up a slight knock this week.
Defender Gretar Steinsson should have recovered from a bug in time for the game, but midfielder Mark Davies is set to miss out due to an ankle injury sustained at St Andrew's.
Jlloyd Samuel and Joey O'Brien have been playing for the reserves after lengthy spells on the sidelines with thigh and knee problems respectively, although both are still some way off being ready for first-team action yet.
Zat Knight (knee) has only just resumed light training, while Sean Davis (knee) and Sam Ricketts (Achilles) are long-term absentees.
Man Utd (from): Van der Sar, Kuszczak, Amos, Smalling, Brown, Evans, Evra, Fabio, Gibson, Scholes, Carrick, Obertan, Park, Bebe, Giggs, Rooney, Berbatov, Hernandez, Owen, King.
Bolton (from): Jaaskelainen, Robinson, Cahill, Wheater, Muamba, Petrov, K Davies, Elmander, Klasnic, Taylor, Alonso, Rodrigo, Cohen, Holden, Steinsson, Blake, Lee, Bogdan, Sturridge.