Tottenham winger Gareth Bale looks set to start his first game in two months after recovering from his back injury.
Ledley King, Jonathan Woodgate (both groin), Younes Kaboul and Wilson Palacios (both knee) are all unavailable but William Gallas could start after scans revealed a hamstring problem he suffered in training on Tuesday was not serious.
Long-term absentee Tom Huddlestone (ankle) took part in training on Friday morning but is still two weeks away from full fitness.
West Ham will be without striker Robbie Keane.
The on-loan Republic of Ireland international is ineligible to face his parent club as the Hammers look for their first win at White Hart Lane since 1999.
However, manager Avram Grant will be boosted by the return of midfielder Gary O'Neil, who was cup-tied for last weekend's FA Cup quarter-final defeat to Stoke.
The Hammers are still without both Jack Collison (knee) and Junior Stanislas (hernia), while Frederic Piquionne and Demba Ba are doubts.
Tottenham (from): Gomes, Pletikosa, Cudicini, Hutton, Gallas, Bassong, Assou-Ekotto, Dawson, Khumalo, Corluka, Bale, Sandro, Jenas, Lennon, Pienaar, Rose, Crouch, Kranjcar, Pavlyuchenko, Defoe, Van der Vaart.
West Ham (from): Green, Jacobsen, Tomkins, Upson, Bridge, Parker, Noble, Hitzlsperger, Piquionne, Spector, Ba, Cole, Boffin, Reid, Da Costa, Boa Morte, Hines, Obinna, O'Neil