Sheffield United will be without defender Johnny Ertl and suspended pair Darius Henderson and Lee Williamson for the Yorkshire derby.
Ertl is waiting for the results of a scan after sustaining what is feared to be a serious knee injury while playing for the reserves in midweek. Henderson and Williamson were sent off in last week's 3-0 defeat at Watford.
Striker Henderson, back in the starting line-up for the first time in 11 months after a hamstring injury against former club Watford last week, was sent off for two yellow card offences.
Midfielder Williamson was shown a straight red card for his aerial challenge on Lloyd Doyley and starts a four-game ban as it was his second dismissal of the season.
Defender Matt Lowton has not trained this week and is doubtful due to a knock sustained in the reserves but midfielder Bjorn Helge Riise, on loan from Fulham, is back in the squad following a hamstring strain.
Leeds boss Simon Grayson has an almost fully-fit squad to choose from, with long-term absentee Patrick Kisnorbo the only member of the squad who is unavailable.
Right-back Paul Connolly is available to return from a month on the sidelines with a hamstring injury and played a full 90 minutes for the reserves in midweek.
However, he is unlikely to start against the Blades due to the impressive form of on-loan Villa youngster Eric Lichaj, who has extended his loan at Elland Road until the end of the season.
Club captain Richard Naylor is also available despite missing the 6-0 reserves win over Gateshead in the week with a knock.
Sanchez Watt, Lloyd Sam and Ross McCormack are all pushing for starting roles after impressing for the second string.