West Ham hope to have Scott Parker fit to face the league leaders.
The midfielder picked up shoulder and calf injuries on international duty with England and was left on the bench for the midweek draw with Ghana. However, he is expected to pass a fitness test and rejoin a squad boosted by the return of Frederic Piquionne and Robbie Keane.
Piquionne missed the goalless draw at Tottenham a fortnight ago with a foot injury but is fit to feature, while fellow striker Keane was ineligible to his face parent club at White Hart Lane.
Jack Collinson (knee) and Junior Stanislas (hernia) are still ruled out.
Park Ji-sung and Anderson could return for United.
South Korean Park is available after recovering from an injury to his right hamstring, while Brazilian midfielder Anderson will also travel to Upton Park following a knee problem.
Former England captain Rio Ferdinand has returned to training following his calf injury but tomorrow's game will come to soon. The defender could be fit for the match with Fulham the following weekend.
Fellow centre-back Nemanja Vidic is fit to return having played in Serbia's Euro 2012 qualifying draw against Estonia in midweek. United still have several injury concerns, though, with Darren Fletcher, John O'Shea and Rafael among others still on the sidelines, while Jonny Evans and Paul Scholes are suspended.
West Ham (from): Green, Jacobsen, Tomkins, Upson, Bridge, Parker, Noble, Hitzlsperger, Piquionne, Spector, Ba, Cole, Boffin, Reid, Da Costa, Boa Morte, Obinna, O'Neil, Keane.
United (from): Van der Sar, Kuszczak, Amos, Smalling, Brown, Vidic, Evans, Evra, Fabio, Gibson, Scholes, Carrick, Obertan, Park, Bebe, Anderson, Giggs, Rooney, Berbatov, Hernandez, Owen, King.