Bottom side Wigan have a clean bill of health.
Latics have had 12 players on international duty over the past fortnight but none have reported back with injuries.
Antolin Alcaraz (Paraguay), Maynor Figueroa and Hendry Thomas (both Honduras) were the last players to return but should have sufficient recovery time.
Gareth Bale and William Gallas are out for Tottenham and are serious doubts for Tuesday's Champions League clash with Real Madrid.
Gallas looks increasingly doubtful for next week's Champions League game at the Bernabeu after breaking down with a knee injury while Bale is struggling to recover from a hamstring problem.
Ledley King (groin), Younes Kaboul (thigh), Jonathan Woodgate (calf) are also out, leaving Michael Dawson and Sebastien Bassong as Spurs' only two fit centre-halves.
Tom Huddlestone could play his first match in almost five months after coming through a friendly against Barnet unscathed.
Wigan (from): Al Habsi, G Caldwell, Gohouri, Figueroa, Alcaraz, Watson, N'Zogbia, Diame, Moses, McCarthy, Rodallega, Stam, Lopez, Thomas, Gomez, McArthur, McManaman, Cleverley, S Caldwell, Sammon, Di Santo, Boyce, Thomas, Pollitt, Kirkland.
Tottenham (from): Gomes, Pletikosa, Cudicini, Hutton, Bassong, Assou-Ekotto, Dawson, Corluka, Bale, Sandro, Jenas, Lennon, Pienaar, Rose, Huddlestone, Modric, Crouch, Kranjcar, Pavlyuchenko, Defoe, Van der Vaart.