Hull will be without midfielder Nick Barmby for the clash due to a calf injury.
Barmby, who struck the equaliser for the Tigers in the 1-1 home draw with Norwich last time out, is expected to be sidelined for up to four weeks.
Tigers boss Nigel Pearson will also be without defender Liam Rosenior again.
Rosenior damaged shoulder ligaments against Norwich and has targeted a return against Watford next week.
Pearson recalled goalkeeper Matt Duke from his loan spell at Derby earlier this week and the 33-year-old is expected to be included as back-up for Brad Guzan, while Vito Mannone is still struggling with a thigh injury.
Pearson has no other new injury or suspension problems as his side look to close the four-point gap on the top six.
Millwall will be without defender Alan Dunne for the trip.
The long-serving full-back starts a two-match ban after he was sent off late on in the 3-3 draw with Cardiff a fortnight ago.
He could be replaced by Jack Smith, who is fit after a thigh injury, at right-back.
Skipper Paul Robinson was forced off during the first half against Cardiff with a cut eye after being caught by Craig Bellamy but he will be fine.
Midfielder Jimmy Abdou faces another couple of weeks out with a knee problem and forward Shaun Batt is a long-term absentee with a cruciate injury.
Goalkeeper David Forde and strikers Steve Morison and Josh McQuoid have returned from international duty unscathed.