Tranmere boss Les Parry is hoping to have Mark McChrystal and Andy Robinson available.
Defender McChrystal is nursing a hamstring injury and winger Robinson was forced off during the first half of Monday's goalless draw at Oldham with a groin strain.
Parry is hopeful that both men will be passed fit to face the Terriers but veteran centre-back Ian Goodison begins a two-match ban after picking up his 10th booking of the season at Boundary Park.
The Jamaican is now ruled out against Huddersfield and the away fixture at Sheffield Wednesday.
Tim Cathalina is set to miss out with an Achilles injury but Rovers have no other major concerns.
Scotland international Gary Naysmith will miss out again as Huddersfield look to extend their unbeaten league run to 19 matches.
Defender Naysmith, who has made only eight league appearances for the Terriers since arriving from Sheffield United in the summer, is struggling with a new knee injury.
Goalkeeper Alex Smithies also remains sidelined with the knee injury that forced him to withdraw from the England Under-21s squad, so Ian Bennett will continue.
Defender Antony Kay is fit again after missing the last four games with an ankle injury and is hoping to be included in the squad, while manager Lee Clark has no other new injury or suspension problems.
Winger Anthony Pilkington (leg/ankle) and midfielder Damien Johnson (knee) are are ruled out for the rest of the season.