St Mirren manager Danny Lennon has a fully-fit squad to choose from against the bottom club.
David Barron is in contention following a long lay-off, while the international break has allowed David van Zanten and Hugh Murray to shake off recent knocks.
The Buddies missed the chance to add to their squad when Maurice Ross signed for Motherwell.
Hamilton have three key players suspended.
Dougie Imrie completes a two-match ban while Mark McLaughlin begins the same punishment and Simon Mensing is out after being sent off in the goalless draw against St Johnstone.
Jon Routledge is a major doubt with a knee problem but Martin Canning returns. Marco Paixao and James Gibson (both knee) remain out.
St Mirren (from): Gallacher, McAusland, Travner, McGregor, Potter, Thomson, Barron, Goodwin, Dargo, Higdon, McLean, Murray, van Zanten, Mair, Mooy, McGowan, Cregg, Wardlaw, Samson.
Hamilton (from): Cerny, Elebert, Canning, Buchanan, Skelton, Neil, McDonald, Carrington, Gillespie, McAlister, Chambers, Flavio Paixao, Crawford, Hasselbaink, Hopkirk, Murdoch, Antoine-Curier, Graham.