Aaron Lennon is a doubt for Tottenham as he continues to struggle with the illness which prompted his late withdrawal from Tuesday's Champions League clash against Real Madrid.
Spurs will give late fitness tests to Lennon, Vedran Corluka (ankle) and Niko Kranjcar (foot) but Steven Pienaar is out with a groin problem.
Younes Kaboul (thigh), Jonathan Woodgate (calf) and Alan Hutton (knee) are unavailable but there is some good news about Ledley King, who has returned to light training after it emerged that he no longer requires a second operation on his groin injury.
Tom Huddlestone could come in for Sandro in midfield to make his first appearance since an ankle injury sidelined him in November.
Stoke defender Danny Higginbotham could be sidelined for up to six months with a cruciate knee ligament injury sustained towards the end of the Potters' 1-1 draw with Chelsea last weekend.
There is better news regarding John Carew, though, with Tony Pulis optimistic the striker, who has missed three games due to a back complaint, will be able to play some part at White Hart Lane.
Two other recent absentees, Thomas Sorensen (back) and Abdoulaye Faye (hamstring), are fit again, while Jermaine Pennant should be available despite picking up a knock in training on Wednesday.
Tottenham (from): Gomes, Cudicini, Pletikosa, Corluka, Assou-Ekotto, Bassong, Gallas, Dawson, King, Lennon, Kranjcar, Huddlestone, Sandro, Modric, Jenas, Rose, Bale, Van der Vaart, Defoe, Crouch, Pavlyuchenko.
Stoke (from): Begovic, Sorensen, Huth, Wilson, Delap, Faye, Etherington, Whitehead, Jones, Collins, Fuller, Carew, Pugh, Whelan, Pennant, Wilkinson, Walters, Shawcross, Diao, Shotton.