Gary Madine and Rob Jones could return for the Owls.
Striker Madine started on the substitutes' bench in last week's defeat at Brighton. His 10-year-old brother was involved in a car accident and the 17-goal forward had missed out on training.
Central defender Jones, on loan from Scunthorpe, has been sidelined for the last three games due to concussion sustained in the recent home defeat to Brentford, but both players are expected to start.
Manager Gary Megson, who has no new injury or suspension worries, could also turn to the likes of winger Gary Teale, along with midfielders Darren Potter and Giles Coke.
Meanwhile, defender Daniel Jones and striker Paul Heffernan are pushing for recalls as the Owls bid to secure a third straight home win and extend the seven-point gap between themselves and the relegation zone.
Hartlepool will still be without Neil Austin and James Brown.
Defender Austin has been sidelined for three months with a calf injury, while striker Brown has been struggling with an ankle problem for the last month.
Both men are on the road to recovery and have been training this week, but they will not be fit in time to make the Hillsborough encounter.
Striker Adam Boyd will aim to continue his goalscoring vow after promising first-team coach Mick Wadsworth he will score in every game between now and the end of the season.
Pools travel to South Yorkshire with little to play for in their remaining five games, though Wadsworth will be keen for his side to finish on a high and earn a top-half finish.