Gareth Bale is a major doubt for Tottenham after sustaining a knee injury in Wednesday's north London derby.
William Gallas and Vedran Corluka (ankle) also picked up knocks in the match and could miss out while Niko Kranjcar is struggling with a foot problem.
Jonathan Woodgate (calf), Ledley King (groin), Wilson Palacios and Alan Hutton (both knee) are all definitely out.
West Brom have no fresh injury concerns.
Midfielder Graham Dorrans is the only absentee with the ankle problem which has sidelined him for the past seven weeks.
Albion are unlikely to risk the Scotland international again this season unless he makes a complete recovery from the setback suffered in training.
Roy Hodgson's side will be looking to bounce back from the 3-1 home reversal against Chelsea after collecting 12 points from the previous six games since the ex Liverpool boss took charge.
Tottenham (from): Gomes, Cudicini, Pletikosa, Corluka, Assou Ekotto, Bassong, Gallas, Dawson, Kaboul, Lennon, Kranjcar, Pienaar, Huddlestone, Sandro, Modric, Jenas, Rose, Bale, Van der Vaart, Defoe, Pavlyuchenko, Crouch.
West Brom (from): Carson, Myhill, Jara, Reid, Zuiverloon, Olsson, Tamas, Pablo, Meite, Shorey, Cech, Scharner, Mulumbu, Brunt, Morrison, Thomas, Vela, Tchoyi, Barnes, Fortune, Odemwingie.