Palace could have James Vaughan and Alex Marrow back in the ranks.
On-loan Everton striker Vaughan sustained an ankle injury in the recent 2-1 defeat to Scunthorpe and subsequently missed Friday's goalless draw with Doncaster.
But he could return to bolster Palace, who are still looking over their shoulder in the Championship given they are just three points above the drop zone.
Marrow, meanwhile, has also been struggling with an ankle injury in recent times, although he too could be available.
Winger Sean Scannell will again miss out as he serves the second game of a three-match ban. Striker Steffen Iversen is pushing for a starting berth.
Leeds have doubts over 20-goal striker Luciano Becchio.
The Argentinian missed Friday night's goalless draw with Reading due to a hamstring strain and may again be unavailable against the Eagles.
Billy Paynter and Max Gradel lined up in attack last time out, but with Davide Somma, Ross McCormack and Sanchez Watt waiting in the wings, Grayson could opt to freshen things up.
His only other problem is the absence of winger Lloyd Sam, who will again be sidelined with a knee injury.