Sunderland boss Steve Bruce will head into the clash without a single senior striker fit.
Asamoah Gyan and Danny Welbeck (both hamstring) are unlikely to play again this season and Fraizer Campbell (knee) is out for a year, while even youngster Ryan Noble damaged a knee on youth team duty earlier this week.
Benin international Stephane Sessegnon is the main candidate for a lone role up front, while full-back Phil Bardsley has recovered from the bout of concussion he suffered during last Saturday's 4-2 victory over Wigan.
John Mensah (adductor tear) and Anton Ferdinand (hamstring) are being assessed, but Kieran Richardson (hamstring) is likely to miss out and Titus Bramble, Craig Gordon and David Meyler (all knee) remain on the sidelines.
Defender Philippe Senderos could make his first appearance for Fulham.
The Switzerland international joined from Arsenal last June but has yet to feature for the Cottagers after picking up a serious Achilles injury.
Senderos was included in the squad for the first time in Wednesday's 3-0 victory over Bolton and could be given a taste of first-team action from the bench at the Stadium of Light.
Fulham manager Mark Hughes will be hoping Damien Duff has recovered from his own Achilles complaint, while Bobby Zamora and Andrew Johnson will be pushing for starts having both come on as substitutes in the last two games.
Sunderland (from): Mignolet, Carson, Onuoha, Ferdinand, Mensah, Bardsley, Angeleri, Turner, Cattermole, Muntari, Riveros, Henderson, Malbranque, Elmohamady, Sessegnon, Zenden, Colback, Knott, Adams, Lynch.
Fulham (from): Schwarzer, Baird, Hangeland, Hughes, Senderos, Salcido, Etuhu, Duff, Davies, Murphy, Sidwell, Dempsey, Duff, Dembele, Zamora, Johnson, Stockdale, Kelly, Gudjohnsen, Kakuta.