Exeter could be at full strength for the derby showdown.
The Grecians' play-off hopes were ended in the crushing defeat at Tranmere but they can have a big say in which division relegation-threatened Argyle will be playing in next season.
Boss Paul Tisdale will assess the fitness of midfielder David Noble after he missed the Rovers clash with a hamstring injury.
But forward Daniel Nardiello and defender Matt Taylor are fully fit again after recovering from knocks.
Goalkeeper Artur Krysiak returned to the side after loanee Ben Hamer returned to parent club Reading and he will start again, with youngster James Wood set to be named among the subs.
City have won five of their last six matches but were beaten 2-0 by Plymouth earlier this season.
Plymouth boss Peter Reid will call on a number of players to play through the pain barrier.
Argyle desperately need the points to boost their survival hopes, but Devon rivals Exeter are looking to finish the season on a high despite being out of the play-off race.
Reid has led his side to three wins in the last four matches to move to within three points of safety, but he has had to rely on a number of walking wounded.
Captain Carl Fletcher, along with midfield duo Kari Arnason and Simon Walton are ready to take on the Grecians, as is striker Rory Fallon.
Walton featured in the 1-0 victory over MK Dons despite carrying an ankle injury, but midfielder Chris Clark (knee) missed out and will be sidelined again.
Striker Rory Patterson is back in contention after serving a one-game ban.