Caretaker manager Paul Bodin takes charge of already-relegated Swindon for the first time.
Bodin, who enjoyed two playing spells with the Robins between 1988-91 and 1992-96, was on Friday promoted from Under-18s manager to take the reins for the final two matches in the wake of Paul Hart's departure as interim boss.
Centre-back Andy Frampton is set to miss out against the Latics having been forced off after 37 minutes against Sheffield Wednesday on Monday with an ankle injury.
Goalkeeper David Lucas (back) and defender Milan Misun (knee) continue to miss out, and have been joined in the treatment room by youngsters Will Evans and Nathan Thompson (both ankle), the latter of whom has a chance of recovering in time for this weekend.
Bodin's son, Billy, has forced his way into contention of late and played the final 20 minutes at Hillsborough. The forward, 19, could be in line for further involvement this weekend and possibly his first start for the club.
Paul Dickov is facing a major injury crisis.
Left-back Cedric Evina hobbled off with an ankle injury after just 23 minutes of the 1-1 draw at home to Walsall on Easter Monday.
He could now miss out and with fellow left-back Paul Black (abdomen) unlikely to feature again this season following recent minor surgery, Dickov is desperately short of defensive options.
Kieran Lee (hamstring), Reuben Hazell (knee), Ryan Brooke (ankle) and Oumare Tounkara (ankle) are all carrying injuries and their fitness will be assessed.
Winger Filipe Morais, who is out of contract in the summer, misses the final two matches of the season after being sent off against Walsall, while fellow wideman Kirk Millar is also banned.