Scott Parker is a major doubt for West Ham.
The England international missed the recent defeats at Chelsea and Manchester City with an Achilles complaint that he is still struggling with, while fellow midfielders Gary O'Neil (ankle) and Mark Noble (hernia) will be absent and defender Matthew Upson is doubtful with a dead leg.
Jordan Spence could feature after being recalled from his loan spell at Bristol City and on-loan Wayne Bridge returns to the squad after being ineligible to face parent club City last weekend.
Blackburn will give late fitness tests to Junior Hoilett, David Dunn and Michel Salgado.
Rovers boss Steve Kean believes at least two of the trio will be available for the Premier League match.
Ryan Nelsen and Vince Grella are definitely out of the Upton Park clash where three points would secure Blackburn's top-flight status.
West Ham (from): Green, Jacobsen, Tomkins, Upson, Hitzlsperger, Piquionne, Spector, Ba, Cole, Boffin, Reid, Da Costa, Boa Morte, Collison, Keane, Spence, Bridge, Parker, Stanislas.
Blackburn (from): Robinson, Samba, Givet, Olsson, Salgado, J Jones, Emerton, P Jones, Nzonzi, Dunn, Diouf, Hoilett, Bunn, Roberts, Pedersen, Hanley, Kalinic, Rochina, Formica, Benjani, Santa Cruz.