Oldham boss Paul Dickov is set to be without a trio of players.
Reuben Hazell (knee), Cedric Evina (ankle) and Kieran Lee (hamstring) are all nursing injuries and none of them are likely to feature against Karl Robinson's side.
Winger Filipe Morais, who is out of contract in the summer, is still suspended after being sent off against Walsall, while fellow wideman Kirk Millar is also banned.
Paul Black has been sidelined for some weeks following surgery for abdominal/hernia problems, so Dickov will field a similar side to the one that beat Swindon 2-0 last weekend.
The team which started at Swindon included five players aged 19 or under with Ryan Burns, a first-year trainee, handed his first-team debut.
George Baldock will make his full debut for MK Dons.
The Dons have secured their place in the League One play-offs and manager Karl Robinson has taken the opportunity to rest some of his first-team players.
Robinson took the unusual step of naming his team on Thursday afternoon which sees Baldock - younger brother of Dons striker Sam - start in midfield.
There are nine changes in all from the side which beat Notts County last week as Stuart Searle makes a rare appearance in goal and youngsters Adam Chicksen and Tom Flanagan start in defence.
Defender Danny Woodards is back in the side after a hamstring strain but midfielder Luke Chadwick injured his shoulder against County and is a doubt for the play-offs.
Midfielder Peter Leven will miss the play-offs after he fractured a metatarsal in an innocuous incident in training on Thursday.