Sheffield Wednesday manager Gary Megson is expected to name an unchanged starting line-up as his side chase a fifth successive home win.
Megson has no new injury or suspension worries but will be without Mark Beevers again for the last match as the central defender nurses a fractured cheekbone.
On-loan pair Rob Jones, from Scunthorpe, and Wolves' Danny Batth are likely to resume their partnership at the heart of Megson's back four.
Striker Gary Madine shook off a calf injury in time to start last week at Bristol Rovers and should continue alongside leading goalscorer Neil Mellor.
Winger Jermaine Johnson and midfielder pair Darren Potter and Chris Sedgwick are pushing for recalls after stepping off the substitutes' bench last week.
The Owls have lost only one of their last seven games, winning four and drawing the other two.
Exeter boss Paul Tisdale looks set to be without midfielder David Noble.
Noble had to be stretchered off during the second half of the 1-0 home win over Plymouth last Saturday after falling awkwardly on his ankle and is a major doubt.
Striker John O'Flynn is definitely sidelined as he continues to struggle with the toe injury that kept him out against Argyle.
Veteran defender Rob Edwards is likely to feature in what will be his final game for the club as he is set to retire after the match. He is expected to start on the bench but should make his 180th appearance for City as a substitute.
Midfielder Ryan Harley should start on his final outing for the Grecians. He signed for Swansea on a free in January but was loaned back to Exeter for the remainder of the campaign.