Guly do Prado looks set to miss Southampton's final game of the season.
The Brazilian attacker sat out Monday's win over Plymouth with the leg injury he suffered at Brentford last Saturday and is not expected to be fit.
With Lee Barnard still sidelined with an ankle injury, veteran striker David Connolly is poised to partner Rickie Lambert in attack again.
Teenage winger Alex Chamberlain is close to being fit after an ankle injury, but with Saints assured of promotion barring an unlikely goal difference swing, he will not be risked unnecessarily.
Full-back Dan Harding could return after a hip injury while midfielder Morgan Schneiderlin (knee) and wideman Lee Holmes (ankle) were back in the squad against Plymouth after lengthy spells out and should be involved again.
Walsall welcome back Emmanuel Ledesma from suspension for their survival showdown.
The Argentinian playmaker completed a three-match ban with the passing of last weekend's vital 2-0 home victory over Charlton, a result which leaves the Saddlers in pole position to retain their League One status on the final day.
But Ledesma is unlikely to find himself in Walsall's starting XI at St Mary's, with manager Dean Smith charged with the decision whether to keep faith with the same XI who saw off the Addicks for what would be a third successive match.
Smith does not have any new injury or suspension worries, with centre-back Clayton McDonald (dislocated shoulder) and full-back Aaron Lescott (knee ligament strain) the only absentees.
Walsall, one point and one place clear of the drop zone, need only to match the result of Dagenham & Redbridge, who travel to Peterborough, to survive, with 22nd-placed Bristol Rovers all but relegated due to their vastly inferior goal difference.