Tranmere boss Les Parry will be without a trio of players.
Enoch Showunmi, Marlon Broomes and Ryan Fraughan remain sidelined though injury but Parry has no other concerns.
Showunmi misses out after breaking his fibula in the game against Exeter recently and Broomes has been on the sidelines for several months after damaging knee ligaments.
Fraughan is ruled out with a calf injury but Rovers are in fine form and go into the match on the back of successive wins over Exeter and Leyton Orient.
A victory for Parry's side could lift them as high as 11th depending on other results.
Parry, meanwhile, is out of contract at the end of the season but is set to be handed a new deal.
Caretaker manager Paul Bodin is set to make one or two changes to his XI as relegated Swindon take part in their last game in League One for at least a year.
On-loan striker Calvin Andrew started last weekend's 2-0 home defeat to Oldham but has now returned to parent club Crystal Palace, as has midfielder Alassane N'Diaye, who was an unused substitute.
That means Elliot Benyon is likely to partner Billy Bodin in attack at Prenton Park.
Defender Aden Flint is back with the club having enjoyed a loan spell with former employers Alfreton Town, whom he helped secure promotion to the Blue Square Bet Premier.
Flint is now in contention for a starting berth against Rovers, while youngsters Nathan Thompson, Miles Storey and Matt Clark could also be involved.
Andy Frampton (ankle), David Lucas (back), Vincent Pericard and Milan Misun (both knee) all continue to miss out through injury, while soon to be out-of-contract defender Alan Sheehan is unlikely to be in the frame having already taken part in a trial spell at Preston.