Morecambe boss Sammy McIlroy looks certain to wield the axe when his side end their campaign at home.
McIlroy was left furious after his side crashed to a 7-2 thumping at Port Vale last weekend.
He hauled off midfielders Kevan Hurst and Garry Hunter as well as striker Danny Carlton in the second half at Vale Park.
Those three and several other players are facing an anxious wait over their inclusion.
Andy Parrish and Andy Fleming are set to miss out again through injury while Paul Scott (knee) and Kieran Charnock (Achilles) remain long-term absentees.
McIlroy is expecting a response to last week's capitulation but he admitted: "It was a few days ago now yet I still can't believe how bad we were."
Northampton manager Gary Johnson is set to name an unchanged squad.
Johnson finally collected his first win in charge against Stevenage last weekend, which secured the club's Football League status, and he is unlikely to make many changes.
Michael Uwezu scored his first professional goal last week and will again partner Shaun Harrad in attack as a whole host of Cobblers players look set for their final appearance in the claret shirt.
Johnson is poised for a radical overhaul of the squad this summer and will again be without a number of injured players.
On-loan Doncaster defender Byron Webster picked up a hamstring injury against Rotherham on Good Friday while striker Leon McKenzie will also miss out with a thigh injury.
Fellow forward Billy McKay is now fit after a dislocated elbow but Guillem Bauza has a rib injury and goalkeeper Steve Collis has a thigh strain.