Dimitar Berbatov will be given the chance to secure the Premier League's Golden Boot prize.
The Bulgarian has scored just two goals since January and is now level with Carlos Tevez on 20, but he will start for Manchester United in a match that will determine Blackpool's top flight future.
Edwin van der Sar will make his final Premier League appearance, with Paul Scholes, Anderson, Patrice Evra and Darren Fletcher also confirmed as starters by Sir Alex Ferguson
Blackpool are expected to be at full strength but Ian Holloway's side have the toughest possible test at United, who have dropped just two points at home all season.
Even a repeat of their last Old Trafford triumph, in 1962, may not be enough to save the Tangerines should other results go against them, although conversely, they could stay up with a narrow defeat.
Manchester United (from): Van der Sar, Kuszczak, Lindegaard, Rafael, O'Shea, Ferdinand, Vidic, Gill, Smalling, Evans, Brown, Evra, Obertan, Bebe, Valencia, Scholes, Anderson, Carrick, Fletcher, Gibson, Park, Giggs, Nani, Tunnicliffe, Rooney, Berbatov, Owen, Hernandez, King.
Blackpool (from): Gilks, Eardley, Cathcart, Crainey, Evatt, Southern, Adam, Varney, Taylor-Fletcher, Campbell, Grandin, Baptiste, Sylvestre, Puncheon, Vaughan, Phillips, Harewood, Ormerod, Beattie, Reid, Kornilenko, Rachubka, Kingson.