West Ham caretaker manager Kevin Keen will include a strong home-grown contingent for the final game season.
Zavon Hines, Jordan Spence, Freddie Sears, Junior Stanislas, James Tomkins and Jack Collison are all likely to feature for the relegated Hammers while Keen said some of those set to leave in the summer will be left out.
They will be without Mark Noble (hernia) and Gary O'Neil (ankle) while player of the year Scott Parker has been hampered by an Achilles problem in recent weeks.
Sunderland are set to have a striker available for the game after Asamoah Gyan returned to training.
The Ghana international is battling back after a hamstring problem, while defender Anton Ferdinand is also back in training and both could make the squad to face the already-relegated Hammers.
Craig Gordon, Titus Bramble, Michael Turner, David Meyler, Fraizer Campbell and Marcos Angeleri are all out with knee injuries, while Kieran Richardson (fractured fibula), Lee Cattermole (back) and Danny Welbeck (hamstring) remain on the sidelines.
West Ham (from): Green, Jacobsen, Tomkins, Upson, Hitzlsperger, Piquionne, Spector, Ba, Cole, Boffin, Reid, Da Costa, Boa Morte, Collison, Keane, Spence, Bridge, Parker, Stanislas, Hines, Sears.
Sunderland (from): Mignolet, Carson, Onuoha, Mensah, Ferdinand, Bardsley, Riveros, Henderson, Malbranque, Elmohamady, Sessegnon, Zenden, Colback, Gyan, Noble, Knott, Adams, Lynch, Laing.