Miguel Llera is suspended and Kelly Youga (knee) is still injured so summer signings Gary Doherty, Simon Francis and Johnnie Jackson will line up alongside Christian Dailly in the back four at The Valley on Saturday.
Alan McCormack starts in midfield following his switch from Southend while Pawel Abbott, the new signing from Oldham, is set for his debut in attack.
Winger Kyel Reid and striker Akpo Sodje should also start after making their loan deals permanent over the summer.
Rob Elliot will reclaim his place in goal after Darren Randolph left to join Motherwell.
West Ham loanee Matt Fry, youngster Yado Mambo and goalkeeper Ross Worner, signed from Woking, will be on the bench.