Sol Campbell, Cheik Tiote and Hatem Ben Arfa are all available for the first time as the Magpies attempt to build upon a solid start to life back in the top flight.
Andy Carroll has resumed training after an ankle injury and Hughton will assess him before making his selection, but Spanish striker Xisco begins a three-match ban following his sending-off for the reserves.
Steven Taylor (shoulder), Danny Simpson and Leon Best (both ankle) are also out, while knee injuries rule out Danny Guthrie and Dan Gosling.
Magpies (from): Harper, Krul, Perch, R. Taylor, Enrique, Coloccini, Williamson, Campbell, Kadar, Smith, Tiote, Barton, Routledge, Gutierrez, Ben Arfa, Vuckic, Nolan, Carroll, Ameobi, Lovenkrands, Ranger.
