Webster is struggling to overcome the metatarsal injury which has kept him on the sidelines so far this season and Rovers are unlikely to risk him.
O'Driscoll will definitely be missing long-term absentees James Chambers and Wayne Thomas (both knee) and James Hayter, who has a hamstring problem.
However, youngster Ryan Mason, on loan from Tottenham, may be in contention for a recall after his late cameo on Saturday when Rovers secured a 2-2 draw at Watford thanks to a 90th-minute George Friend equaliser.
Doncaster have won just one of their 10 meetings with Norwich, which came in September 1935, and have lost on eight occasions.
