Leeds will be without suspended winger Robert Snodgrass for the home clash with Preston.
Snodgrass, who recently returned from a knee injury and made only his second appearance of the season in Saturday's win over Sheffield United, is serving a one-game ban after being sent off for a second bookable offence.
He replaced Lloyd Sam at the weekend, so the latter can expect to start again, although manager Simon Grayson has plenty of options in all areas.
Grayson must decide whether to stick with Bradley Johnson, preferred in central midfield to Neil Kilkenny, while Sanchez Watt and Amdy Faye, yet to make his first appearance for the club, were unused substitutes on Saturday.
Luciano Becchio partnered Davide Somma up front against the Blades, but Ross McCormack and Ramon Nunez could also come into contention.
North End boss Darren Ferguson could be without Wayne Brown for the clash at Elland Road due to a hamstring injury sustained in the 2-1 win at Coventry on Saturday.
Callum Davidson, who recently overcame a calf strain, returned to the starting line-up at the Ricoh Arena and is expected to retain his place after coming through the encounter unscathed.
On-loan Manchester United pair Matt James and Josh King will again miss out as they continue to struggle with respective ankle injuries, although the latter could return for the game against Reading on Saturday.
North End ended a five-match losing streak to secure just their second win of the season against the Sky Blues and move off the foot of the table.