Reading will be without defender Zurab Khizanishvili for the visit of Ipswich.
The on-loan Blackburn man was sent off during the 3-0 win over Barnsley on Saturday for a second bookable offence and will serve a one-match ban.
Alex Pearce will return in his place with the Royals looking for another home win.
Midfielder Brian Howard is also sidelined through suspension as he sits out the second of his three-game ban.
Jay Tabb's ankle injury rules him out, while the game is likely to come too soon for Andy Griffin and Julian Kelly as both continue to recover from hamstring injuries.
Ivar Ingimarsson could be fit enough to take his place on the bench and Chris Armstrong, who made his first start in a year on Saturday after recovering from a serious knee injury, could again play.
Ipswich manager Roy Keane must decide whether to keep faith with teenage striker Connor Wickham.
The 17-year-old gave the ball away in the build up to Scunthorpe's opener on Saturday and was immediately replaced by Keane as he switched to a 4-1-4-1 formation after just 32 minutes.
Wickham could be back on the bench at the Madejski as midfielder Luke Hyam was impressive after replacing him.
Jaime Peters will also be hoping for a recall at right-back after the Canadian came off the bench to score the equaliser at Glanford Park.
Tottenham midfielder Jake Livermore was an unused substitute on Saturday and will be hoping for his Town debut but Luciano Civelli will be absent again as he continues to recover from a serious knee injury.