Ipswich will be without midfielders Luke Hyam and David Norris.
Teenager Hyam was sent-off for two bookable offences during the 1-0 defeat at Reading in midweek while captain Norris collected his fifth booking of the season and the pair will both serve one-match bans.
Roy Keane could hand a first start to on-loan Tottenham man Jake Livermore in place of Norris while 17-year-old striker Connor Wickham could also return should the manager choose to revert to 4-4-2 at home.
Winger Luciano Civelli will be absent again as he continues to recover from a serious knee injury but Keane has no other new injury concerns for the game.
Leeds winger Robert Snodgrass is expected to come back into contention for the clash following suspension.
Snodgrass, who has made only two appearances for United this season, was sent off in his second comeback game against Sheffield United last week following a knee injury sustained during the summer.
Simon Grayson has no new injury concerns, but could be tempted to make changes after seeing his side concede a 4-1 lead to lose 6-4 at home to Preston in midweek, meaning Snodgrass could start.
Skipper Richard Naylor, who has sat on the substitutes' bench for the last three matches, will be keen to return to the side against his former club.
Midfielder Amdy Faye and striker Ramon Nunez have both been waiting patiently for their first appearances for the club and could play, while goalkeeper Kasper Schmeichel is not expected to return from a foot injury until early next month.