Everton are without midfielder Marouane Fellaini, who suffered a hamstring injury playing for Belgium in midweek and faces up to six weeks on the sidelines.
Defender Phil Jagielka is also unlikely to feature in the crunch Premier League clash after straining a hamstring in training with England.
Playmaker Steven Pienaar is still out with a groin injury and striker Louis Saha (calf) is rated as unlikely to return by manager David Moyes.
Jack Rodwell (ankle) is a long-term absentee while youngster Ross Barkley, on the bench for the last four games, suffered a broken leg this week.
Striker Fernando Torres is fit to face Everton in the 214th Merseyside derby.
The Spain striker sustained an adductor injury in the 2-1 defeat to Blackpool almost a fortnight ago but has been declared fit by manager Roy Hodgson.
Defender Paul Konchesky has recovered from a hamstring strain while fellow left-back Fabio Aurelio has overcome an Achilles problem which has kept him out since late August.
Centre-half Daniel Agger is a doubt with a back injury sustained playing for Denmark this week and Holland forward Dirk Kuyt has been ruled out for at least three weeks after injuring his ankle on international duty.
Everton (from): Howard, Neville, Distin, Heitinga, Baines, Hibbert, Cahill, Osman, Arteta, Beckford, Bilyaletdinov, Gueye, Coleman, Yakubu, Mustafi, Silva, Baxter, Wallace, Mucha.
Liverpool (from): Reina, Johnson, Carragher, Skrtel, Konchesky, Poulsen, Gerrard, Meireles, Cole, Torres, Ngog, Jones, Aurelio, Kyrgiakos, Lucas, Spearing, Jovanovic, Rodriguez, Babel.